Endogenous DNA damage clusters in human skin, 3-D model, and cultured skin cells
نویسندگان
چکیده
منابع مشابه
Antioxidant Induces DNA Damage, Cell Death and Mutagenicity in Human Lung and Skin Normal Cells
Clinical trials have shown that antioxidant supplementation increased the risk of lung and skin cancers, but the underlying molecular mechanism is unknown. Here, we show that epigallocatechin gallate (EGCG) as an exemplary antioxidant induced significant death and DNA damage in human lung and skin normal cells through a reductive mechanism. Our results show direct evidence of reductive DNA dama...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2005
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2005.05.008